Demineralization prevention with a new antibacterial restorative composite containing QASi nanoparticles: an in situ study

Peter Rechmann & Charles Q. Le & Benjamin W. Chaffee & Beate M.T. Rechmann, Clin Oral Invest, February 2021


A self-control (split-mouth) clinical study, performed by Prof Rechmann at UCSF (n=25), shows 68% reduction in mineral loss using an in-situ caries model.

Benefit observed in all cases. Follow up=30 days.

The in situ clinical study has shown that composites with Nobio’s QASi antibacterial particles significantly reduced demineralization in enamel adjacent to a 38 um gap of an in situ gap model in comparison to a conventional composite, with mineral loss evaluated by cross sectional microhardness testing in the laboratory. The evaluated mineral loss in the enamel slabs was in each case lower on the side with the Nobio composite when compared individually with the side carrying the control composite.

Infinix significantly reduced mineral loss, which is part of the caries formation process.